Computational fluid dynamics (CFD) can be used to influence decisions early in the design process. In order to assess the state-of-the-art of CFD and its predictive capability for medical devices, the U.S. Food and Drug Administration (FDA) developed two benchmark models for validation. Previous work explored hybrid and multi-block structured meshing strategies and their impact on steady-state solution accuracy for one of the benchmark cases, a centrifugal blood pump. In this case study, the focus was to extend the previous study by examining the influence of the turbulence model. The k-ω SST, standard k-ε and realizable k-ε turbulence models were used. Results from all six pump test conditions were compared for each turbulence model.